Adjunctive therapy for adults & childn >4 yr who are inadequately controlled on conventional 1st-line antiepileptics for partial onset seizures w/ or w/o secondarily generalized seizures, seizures associated w/ Lennox-Gastaut syndrome, primary generalized tonic clonic seizures. Monotherapy in patients w/ newly diagnosed epilepsy or for conversion to monotherapy in patients w/ epilepsy. Adjunctive therapy for adults & childn (>2 yr) w/ partial-onset or generalized tonic-clonic seizures.
Adult Initially 25-50 mg nightly for 1 wk, increased at wkly intervals by 25-50 mg/day in 2 divided doses. Effective dose: 200-400 mg daily in 2 divided doses. Max: 800 mg daily. Childn ≥4 yr Initially 25 mg for the 1st wk, increased at intervals of 1-2 wk by increments of 1-3 mg/kg/day in 2 divided doses if >25 mg/day. Recommended dose thereafter: 5-9 mg/kg/day in 2 divided doses.
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